Bladder Cancer Causes and Risk Factors (2024)

Bladder cancer is caused by certain changes in how bladder cells function, especially how they grow and divide into new cells. There are many risk factors for bladder cancer, but many do not directly cause cancer. Instead, they increase the chance of DNA damage in cells that may lead to bladder cancer. To learn more about how cancer develops, see What Is Cancer?

A risk factor is anything that increases the chance of getting a disease. Some risk factors for bladder cancer, like using tobacco, can be changed. Risk factors also include things people cannot change, like their age and family history. It’s important to learn about risk factors for bladder cancer because it can help you make choices that might lower your risk of getting it.

Risk factors for bladder cancer

In the United States, bladder cancer occurs more often in men than in women, and more often in White individuals than in Black individuals. Bladder cancer can be diagnosed at any age, but the risk increases as a person gets older.

Using tobacco, especially smoking cigarettes, is a major risk factor for bladder cancer. Tobacco contains harmful chemicals called carcinogens. When you use tobacco, these chemicals get absorbed into the bloodstream, are filtered by the kidneys, and then collect in the urine. This exposes your bladder to high levels of these chemicals, which can damage the DNA in the cells lining your bladder. Learn about different tools to help you quit smoking and how to use them.

Other risk factors for bladder cancer include

  • having a family history of bladder cancer
  • having certain changes in the genes that are linked to bladder cancer, such as HRAS, RB1, PTEN/MMAC1, NAT2, and GSTM1
  • being exposed to paints, dyes, metals, or petroleum products in the workplace
  • past treatment with radiation therapy to the pelvis or with certain anticancer drugs, such as cyclophosphamide or ifosfamide
  • taking the Chinese herb Aristolochia fangchi
  • drinking water from a well that has high levels of arsenic
  • drinking water that has been treated with chlorine
  • having a bladder infection caused by a parasite called Schistosoma haematobium, which is common in Africa and the Middle East but rare in the United States
  • using urinary catheters for a long time

Having one or more of these risk factors does not necessarily mean you will get bladder cancer. Many people with risk factors never develop bladder cancer, while others with no known risk factors do. Talk with your doctor if you think you might be at risk of bladder cancer. Bladder cancer screening options may be available to you.

Bladder Cancer Causes and Risk Factors (2024)

FAQs

What is the main cause of bladder cancer? ›

The most common risk factor for bladder cancer is cigarette smoking, although smoking cigars and pipes can also raise the risk of developing bladder cancer. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers. Learn more about tobacco's link to cancer and how to quit smoking. Age.

What is the strongest risk factor for bladder cancer? ›

Smoking. Smoking is the most important risk factor for bladder cancer. People who smoke are at least 3 times as likely to get bladder cancer as people who don't. Smoking causes about half of all bladder cancers.

What is usually the first symptom of bladder cancer? ›

For most people, the first symptom of bladder cancer is blood in the urine, also called hematuria. Sometimes the blood is visible, prompting the patient to visit a doctor.

Who most commonly gets bladder cancer? ›

Age: Most people who get bladder cancer are older in age. The average age at diagnosis is 73, and 90 percent of patients are over age 55. Race: Bladder cancer is twice as common among Caucasians as African Americans. This disease is less common among Hispanics, Asians and Native Americans.

What is life expectancy with bladder cancer? ›

The 5-year relative survival rate of people with bladder cancer that has not spread beyond the inner layer of the bladder wall is 96%. Almost half of people are diagnosed with this stage. If the tumor is invasive but has not yet spread outside the bladder, the 5-year relative survival rate is 70%.

Is bladder cancer usually curable? ›

Non-muscle-invasive bladder cancer can often be cured. For muscle-invasive bladder cancer, prognosis also depends on whether carcinoma in situ is also present.

What is the red flag for bladder cancer? ›

Blood in the urine is the most common symptom of bladder cancer. Around 80 out of 100 people with bladder cancer (around 80%) have some blood in their urine. Doctors call blood in the urine haematuria (pronounced heem-at-you-ree-ah). You may see the blood in your urine.

How long can you have bladder cancer without knowing? ›

Can bladder cancer go undetected for years? If symptoms such as blood in the urine and changes in urinary habits are ignored by an individual and/or repeatedly misdiagnosed, it's possible that bladder cancer may not be detected for months or, in some cases, even years.

Do most people beat bladder cancer? ›

If the cancer is just on the inner lining of the bladder (stage 0 or carcinoma in situ), the 5-year survival rate is about 98%. If the cancer is growing just beyond the inner lining into the bladder wall, but is still just in the bladder (Stage I), the 5-year survival rate is about 88%.

What hurts when you have bladder cancer? ›

These include: Blood in the urine, known as hematuria. Frequent urinary tract infections. Pain in flank, the section of the back between the ribs and the hip bone.

What does Stage 1 bladder cancer feel like? ›

The first sign of bladder cancer is blood in the urine, which is painless for most people. In the early stages, this may be your only symptom, though some people don't experience it. Other symptoms include changes in bladder habits, frequent urinary infections, and pelvic or back pain, which might be on one side.

What can be mistaken for bladder cancer? ›

Bladder Cancer is a heterogeneous disease; the main symptom is painless hematuria. However, patients with Bladder Cancer may initially be misdiagnosed as Cystitis or infection, and cystoscopy alone may sometimes be misdiagnosed as urolithiasis or Cystitis, thereby delaying medical attention.

Does bladder cancer spread quickly? ›

Bladder cancer spreads at different speeds depending on the type of bladder cancer you have. Urothelial bladder cancer is slow to spread, while other types are much faster. Urothelial bladder cancer is the most common type of bladder cancer. It typically doesn't spread very quickly.

Where is the first place bladder cancer spreads? ›

Where can bladder cancer spread to? Not all bladder cancers will spread. But If it does it's most likely to spread to the structures close to the bladder, such as the ureters, urethra, prostate, vagin*, or into the pelvis. This is called local spread.

What are the signs that bladder cancer is getting worse? ›

If bladder cancer reaches an advanced stage and begins to spread, symptoms can include:
  • pelvic pain.
  • bone pain.
  • unintentional weight loss.
  • swelling of the legs.
Nov 13, 2023

Do most people survive bladder cancer? ›

Around 80 out of 100 people (around 80%) survive their cancer for 5 years or more after they are diagnosed. Stage 1 means that the cancer has started to grow into the connective tissue beneath the bladder lining.

What foods should be avoided with bladder cancer? ›

Eating small meals throughout the day when you have an appetite is really important to make sure you avoid overeating when you get too hungry. Stay on top of your liquids and try to eat things at room temperature and avoid foods that are greasy, sugary and spicy when you are on a bladder cancer diet.

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